pI: 8.4797 |
Length (AA): 976 |
MW (Da): 108732 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 10 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
19 | 79 | 5vrh (A) | 341 | 413 | 42.00 | 0.64 | 0.18 | 0.2435 | 1.06 |
206 | 370 | 2nqt (A) | 49 | 199 | 29.00 | 0.74 | 0.23 | 0.100057 | 1.21 |
269 | 504 | 3q13 (A) | 198 | 416 | 36.00 | 0 | 1 | 0.538403 | -0.41 |
270 | 495 | 3d34 (A) | 9 | 218 | 29.00 | 0 | 1 | 0.454157 | -0.57 |
597 | 639 | 4hqo (A) | 243 | 278 | 47.00 | 0.32 | 0.17 | 0.249057 | 0.81 |
721 | 776 | 1g6x (A) | 4 | 58 | 36.00 | 0 | 0.99 | 0.502977 | -0.49 |
722 | 870 | 1bik (A) | 26 | 132 | 31.00 | 0.009 | 1 | 0.0966639 | 0.65 |
826 | 872 | 1kth (A) | 5 | 57 | 40.00 | 0.00055 | 1 | 0.410156 | 0.07 |
836 | 870 | 2jot (A) | 20 | 52 | 48.00 | 0.0055 | 0.99 | 0.394861 | 1.49 |
919 | 973 | 1szl (A) | 441 | 493 | 21.00 | 0 | 0.23 | 0.222952 | -0.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_132084)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_02305 | Kunitz/Bovine pancreatic trypsin inhibitor domain containing protein |
Brugia malayi | Bm1_20750 | Thrombospondin type 1 domain containing protein |
Caenorhabditis elegans | CELE_F10E7.4 | Protein SPON-1 |
Drosophila melanogaster | Dmel_CG30203 | CG30203 gene product from transcript CG30203-RB |
Drosophila melanogaster | Dmel_CG17739 | CG17739 gene product from transcript CG17739-RA |
Drosophila melanogaster | Dmel_CG30046 | CG30046 gene product from transcript CG30046-RC |
Drosophila melanogaster | Dmel_CG6953 | CG6953 gene product from transcript CG6953-RA |
Echinococcus granulosus | EgrG_000419200 | trypsin inhibitor |
Echinococcus granulosus | EgrG_000929500 | SPONdin extracellular matrix glycoprotein |
Echinococcus multilocularis | EmuJ_000419200 | trypsin inhibitor |
Echinococcus multilocularis | EmuJ_000929500 | SPONdin (extracellular matrix glycoprotein) |
Homo sapiens | ENSG00000262655 | spondin 1, extracellular matrix protein |
Loa Loa (eye worm) | LOAG_09293 | SPON-1 protein |
Mus musculus | ENSMUSG00000038156 | spondin 1, (f-spondin) extracellular matrix protein |
Onchocerca volvulus | OVOC13508 |
|
Schistosoma japonicum | Sjp_0018610 | IPR002223,Proteinase inhibitor I2, Kunitz metazoa;IPR000884,Thrombospondin, type I,domain-containing |
Schistosoma japonicum | Sjp_0018640 | Spondin-1 precursor, putative |
Schmidtea mediterranea | mk4.000763.10 | |
Schmidtea mediterranea | mk4.004214.00 | |
Schmidtea mediterranea | mk4.001820.01 | |
Schmidtea mediterranea | mk4.000763.12 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.